| No. 1 Picks | Pos. | Draft | Team |
|---|---|---|---|
| Cam Newton | QB | 2011 | Panthers |
| Aundray Bruce | LB | 1988 | Falcons |
| Bo Jackson | RB | 1986 | Raiders |
| Tucker Frederickson | RB | 1965 | Giants |
*Source: NFL All-Time No. 1 Picks
| First Round | Pos. | Draft | Team | Overall Pick |
|---|---|---|---|---|
| Derrick Brown | DT | 2020 | Panthers | 7 |
| Noah Igbinoghene | CB | 2020 | Dolphins | 30 |
| Greg Robinson | OT | 2014 | Rams | 2 |
| Dee Ford | DE | 2014 | Chiefs | 23 |
| Cam Newton | QB | 2011 | Panthers | 1 |
| Nick Fairley | DT | 2011 | Lions | 13 |
| Ben Grubbs | G | 2007 | Ravens | 29 |
| Ronnie Brown | RB | 2005 | Dolphins | 2 |
| Carnell Williams | RB | 2005 | Buccaneers | 5 |
| Carlos Rodgers | DB | 2005 | Redskins | 9 |
| Jason Campbell | QB | 2005 | Redskins | 25 |
| Kendall Simmons | G | 2002 | Steelers | 30 |
| Takeo Spikes | LB | 1998 | Bengals | 13 |
| Victor Riley | OT | 1998 | Chiefs | 27 |
| Willie Anderson | OT | 1996 | Bengals | 10 |
| Wayne Gandy | OT | 1994 | Rams | 15 |
| Aundray Bruce | LB | 1988 | Falcons | 1 |
| Brent Fullwood | RB | 1987 | Packers | 4 |
| Bo Jackson | RB | 1986 | Raiders | 1 |
| Gerald Robinson | LB | 1986 | Seahawks | 14 |
| Chris Woods | WB | 1984 | Raiders | 28 |
| James Brooks | RB | 1981 | Chargers | 24 |
| Reese McCall | TE | 1978 | Colts | 25 |
| Terry Beasley | WR | 1972 | 49ers | 19 |
| Forrest Blue | C | 1968 | 49ers | 15 |
| Tucker Frederickson | RB | 1965 | Giants | 1 |
| Ken Rice | T | 1961 | Bills | 3 (AFL) |
| Jackie Burkett | LB | 1959 | Colts | 12 |
| Jim (Red) Phillips | OE | 1958 | Lions | 5 |
| Joe Childress | HB | 1956 | Cardinals | 7 |
| Dave Middleton | OE | 1955 | Lions | 12 |
| Travis Tidwell | QB | 1950 | Giants | 7 |